Possible Interaction: Glutamine and Histidine

“ Glutamine transport was inhibited in … depolarising conditions using histidine , which shares most transport routes with glutamine, or 2‐(methylamino)isobutyric acid (MeAIB), a specific inhibitor of the neuronal system … entered a large, slow turnover pool, probably located in neurons, which did not interact with the glutamate/glutamine neurotransmitter cycle.”

“Perfusion with 10 mm leucine, lysine, and histidine increased the rates of release of both glutamine and alanine.”

“It catalyzes antiport of His and some neutral amino acids such as Ile, Leu, Val, Cys, Met, Gln and Phe thus being involved in amino acid metabolism.”

“However, in these alleles the glutamine stretch was interrupted by histidines.”

“Our study suggests that substitution of histidines by glutamines induces a conformational change which results in decreased solubility and increased aggregation.”

“ L-glutamine competitively inhibited sodium-dependent L-histidine uptake.”

“We conclude that HIS supplementation increases ammonia production, alanine and glutamine synthesis in muscles, affects turnover of proteins and HIS-containing peptides, and increases requirements for glycine and methionine.”

“In muscles from untreated animals, decreased leucine oxidation after the addition of GLN to the medium was associated with decreased protein synthesis in the SOL and decreased concentrations of serine, glycine, histidine , alanine, arginine, proline, and lysine in both muscles.”

“Increased AQP4 and&agr;-syntrophin levels were inhibited by L-histidine , an inhibitor of glutamine transport into mitochondria, suggesting a role for glutamine in the increase of PM levels of AQP4.”

“Accumulation of glutamine into the mitochondrial matrix was inhibited by histidine (15 mM).”