Possible Interaction: Glutamine and Glycine

“Positive correlations were found between glutamine uptake and the production of citrulline (r=0.814, P=0.0013) and glycine (r=0.734, P=0.0080).”

“We now think that glycine is not a good control for glutamine because both have a trophic effect on intestinal mucosa.”

“Dialytic clearances of glutamine and glycine may prevent further ammoniagenesis in hyperammonemic patients.”

“This is done by eliminating the uncoupled resonance of glycine and the weakly coupled multiplets of glutamate and glutamine , and by selectively suppressing the strongly coupled taurine multiplet 3‐fold.”

“ GLY enhanced GSH levels under GLN starvation, but caused a diminution of GSH content under optimal GLN supply.”

“With excess glutamine , the availability of glycine was limiting.”

“In muscles from untreated animals, decreased leucine oxidation after the addition of GLN to the medium was associated with decreased protein synthesis in the SOL and decreased concentrations of serine, glycine , histidine, alanine, arginine, proline, and lysine in both muscles.”

“Infusion of amino acids such as glutamine plus glycine (2 mM each) also caused increase in liver cell volume as evidenced by the increase in liver mass by 8.9%, and inhibition of [(3)H]leucine release by 29%.”

“Increase of hepatic cell volume by 9%, due to addition of glutamine plus glycine (5 mM each) to the isotonic control incubation medium, led to a significant increase of protein synthesis by 14%.”

“The effects of Glycyl-glutamine dipeptide is better than single Gly or Gln, indicating that the protective effect on myocardial function after severe burns by Gln and Gly is synergistic.”