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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Glutamine
supplement:
Glutathione
Research Papers that Mention the Interaction
“Subsequent experiments with A549 and H460 lung tumor cell lines provided additional evidence for glutamine ’s role in driving synthesis and excretion of GSH.”
Glutaminase inhibitor CB-839 increases radiation sensitivity of lung tumor cells and human lung tumor xenografts in mice“In Mock cells, glutamine deprivation-induced oxidative stress indices were suppressed by treatment with glutamine or GSH or both glutamine and GSH.”
“Animal studies are suggesting that GLN could actually decrease tumour growth by upregulating the immune system and through a regulation of the redox status associated to the metabolism of glutathione.”
“ Glutamine administration increased GSH levels (7.6 ± 1.7 nmol/mg protein vs. 4.03 ± 0.5 in control, p < 0.05) and reduced lipid‐peroxidation (MDA 2.45 ± 0.7 nmol/mg of protein vs. 6.54 ± 1.7 in control; p < 0.05).”
“Supplementation with glutamine influences uptake by both the gut and the immune system, as evidenced by increased mucosal glutamine concentrations and gut glutathione production.”
“Furthermore, glutamine starvation decreased the GSH levels and CDDP resistance in A2780cis cells.”
“Furthermore, Gln exerts potent antioxidant and anti-inflammatory effects in the circulation by inducing the expression of heme oxygenase-1, heat shock proteins, and glutathione.”
“Ursodeoxycholic acid, melatonin and glutamine also block the inhibition of Ca2+ transport caused by GSH depleting drugs.”
“ Q significantly increased activity of SOD, GR and GSH content and decreased activity of GPX in nicotine + Q groups.”
“ Glutamine withdrawal depletes the endogenous antioxidant glutathione ( GSH ), which results in the oxidation of OCT4 cysteine residues required for its DNA binding and enhanced OCT4 degradation.”
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