Possible Interaction: Glutamine and Glutamate

“… L-glutamine (0.5 and 2 … of L-glutamine, L-glutamate and L-aspartate and decreased NO synthesis by EC in a concentration-dependent manner in the presence or absence … substance P. L-Glutamine had no effect on L-arginine uptake by EC or on intracellular L-arginine concentration.”

“The glutamine synthetase L-glutamate :ammonia ligase (ADP) EC 6.3.1.2) activity of many mammalian cells in culture decreases with increasing glutamine concentrations in the medium [l-4].”

“ Glutamine accelerates the degradation of glutamine synthetase (GS, L-glutamate :ammonia ligase (ADP) EC 6.3 .1.2) in cultured rat hepatoma (HTC) cells [ 11.”

“In glutamine-preloaded chloroplasts the uptake of glutamine was inhibited only by l-glutamate.”

“Glycine and L-alanine are Vmax inhibitors, whereas L-glutamine , glucosamine-6-P, GDP, and CTP alter the binding of L-glutamate.”

“A bicarbonate-dependent cleavage of ATP was shown to take place in the absence of L-glutamine; L-glutamate was a competitive inhibitor of L-glutamine and the enzyme was shown to synthesize ATP when incubated with ADP and carbamyl phosphate.”