Possible Interaction: Glutamine and Cpt-11

“ Glutamine treatment prevented the reduced abundance of major bacterial groups after CPT-11 administration; i.e. total bacteria, Clostridium cluster VI, and the Bacteroides-group.”

“ Oral glutamine partially mitigated CPT-11 toxicity and induced temporary changes of the intestinal microbiota.”

“These results draw into question the common assumption that there are additive or synergistic benefits of combinations of nutrients, which are beneficial on an individual basis, and suggest that co-supplementation with glutamine and n-3 PUFA is not indicated during chemotherapy with CPT-11 and 5-FU.”

“ Glutamine … CPT-11 treatment (P < 0.05) and was associated with potentially beneficial and protective responses in the colon: 1) a 3.1- to 7.2-… (P < 0.05); and 4) increased proportions of CD3+CD8+ lymphocytes and memory CD8+ subset in mesenteric lymph nodes following CPT-11 therapy.”

“…,oral glutamine bolus (0.75 g/… to each CPT-11 treatment reduced the incidence of severe diarrhea (34.1 ± 4.7% versus 53.8 ± 4.2%, P < 0.005) and … area under the curve of diarrhea score (16.5 ± 1.0 versus 18.8 ± 0.5, P < 0.05).”