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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
supplement:
Glutamine
drug:
Bedaquiline
Research Papers that Mention the Interaction
“We demonstrate that in addition to inhibiting its primary target, ATP synthase, BDQ causes a secondary inhibition of glutamine biosynthesis that is not directly antimycobacterial but renders Mycobacterium tuberculosis hypersensitive to inhibitors of its glutamine synthetase.”
Mode-of-action profiling reveals glutamine synthetase as a collateral metabolic vulnerability of M. tuberculosis to bedaquiline
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