Possible Interaction: Glutamine and Aspartate

“Substitution of glycine, glutamine or serine attenuated the extent of block whereas the negatively charged aspartate enhanced it, consistent with the side chain of the native asparagine at this position contributing to a blocking site for intracellular Mg2+.”

“The transamination of aspartate and deamidation of glutamine show, respec”

“In addition our results show that co-application of l-Asp and l-Glut facilitates each other's effect, which is at least in part an excitatory amino acid (EAA) transporter dependent process.”

“Testing the interactions of l-Asp and l-Glu in these striatal neurons we found that co-application of l-Asp and l-Glut produced significantly larger inward currents than l-Asp or l-Glut alone.”

“Collectively, glutamine dynamically modulates the bacterial metabolism of the arginine family of AA as well as the serine and aspartate families of AA and reduced the catabolism of most AA (including nutritionally essential and nonessential AA) in jejunal or ileal mixed bacteria.”

“ Gln reduced the astrocytic uptake of D‐[3H]aspartate , but, in contrast to the earlier reported effect of ammonia, this reduction was not accompanied by decreased expression of the astrocytic glutamate transporter GLT‐1 mRNA.”

“As previously shown, a time-dependent increase in aspartate was equaled by a reciprocal decrease in glutamate/glutamine.”

“Replacement of the aspartate with alanine, asparagine, glutamate, or glutamine in Nt-FDH resulted in complete loss of hydrolase activity.”

“Elevation of alanine and aspartate concentrations to 5 mM increased glutamine synthesis in both a substrate- and segment-dependent manner.”

“Adding glutamine at CSF concentration prevented the loss of aspartate and glutamate and revealed an enhancement of aspartate in the terminals at moderate depolarization.”

“… L-glutamine (0.5 and 2 mM) … L-glutamine, L-glutamate and L-aspartate and decreased NO synthesis by EC in a concentration-dependent manner in the presence or absence of A23187, …. L-Glutamine had no effect on L-arginine uptake by EC or on intracellular L-arginine concentration.”