supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
supplement:
Glutamine
supplement:
Alpha-Ketoglutaric Acid
Research Papers that Mention the Interaction
“However, enhanced glutamine flux increases α-ketoglutarate levels, which in turn increases proline and lysine hydroxylation on collagen.”
HIF-1α metabolically controls collagen synthesis and modification in chondrocytes“Limited glutamine availability also prevents CD8 T-cell dysfunction induced by menin deficiency, and its inhibitory effect is antagonized by α-ketoglutarate (α-KG), an intermediate metabolite of glutaminolysis.”
“In the presence of glutamine the addition of 0.5 mM α-ketoglutarate decreased the deamidation of [U- 14 c]-glutamine, a finding which was accompanied by significant amination of [U- 14 c]-α-ketoglutarate.”
“High glutamate/glutamine concentrations abolish the need for glutamate production from α-ketoglutarate and due to metabolic coupling between glutamate synthesis and oxidation these high concentrations render AAT-mediated glutamate oxidation impossible.”
Glutamine-Glutamate Cycle Flux Is Similar in Cultured Astrocytes and Brain and Both Glutamate Production and Oxidation Are Mainly Catalyzed by Aspartate Aminotransferase
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback