Possible Interaction: Glutamine and Aldesleukin

“We found that glutamine at various concentrations significantly enhanced IL-2 production, cell proliferation, and cell viability of Jurkat T cells.”

“We found that glutamine at an optimal concentration (0.6 mM) significantly enhanced PHA-stimulated lymphocyte proliferation as well as Th1 [interferon-gamma (IFN-gamma) and interleukin-2 (IL-2)] and Th2 cytokine (IL-4 and IL-10) production.”

“ Dietary l-glutamine … IL-2 levels on the 3rd (P< 0·01), 5th (P< 0·01), 7th (P< 0·05) and 9th dpi, significantly (P< 0·05) … significantly decreased (P< 0·01) serum IL-10 levels on the 9th and 11th dpi, compared with those in the control group.”

“As the concentration of glutamine increased there was a 2.7-fold increase in the concentration of IL-2 in the culture medium.”

“In these conditions, the IL-2 concentration in the medium increased 39-fold as the glutamine concentration increased.”

“Administration of IL-2 (5.0 micrograms kg-1) induced a slight but statistically significant increase in glutamine concentrations in both brain areas, while similar administration of IL-1 beta (20 micrograms kg-1) significantly reduced the hippocampal levels of glutamine, glutamic acid and GABA.”

“In addition, GLN reduced GSH levels in tumor tissues, but increased the levels of GSH in plasma, improved the T-lymphocyte transformation rate and NK cell activity, significantly inhibited the secretion of TNF-α and promoted the secretion of IL-2 , thus regulating the immune function in vivo.”