Possible Interaction: Glutamine and Alanylglutamine

“Hammarqvist F, Wernerman J, von der Decken A, et al: Alanyl-glutamine counteracts the depletion of free glutamine and the postoperative decline in protein synthesis in skeletal muscle.”

“Hammarqvist F, Wernerman J, von der Decken A, Vinnars E. Alanyl-glutamine counteracts the depletion of free glutamine and post-operative decline in protein synthesis in muscle.”

“On top of this, the restoration of GLN levels might also be affected by the timing of ALA-GLN implementation. *”

“In addition, ALA-GLN dipeptide supplementation produced a marginal increase in plasma levels of alanine, glutamine and citrulline [2].”

“ ALA-GLN dipeptide supplementation produced a small increase in plasma levels of glutamine and citrulline.”

“Administration of ALA-GLN dipeptide increased the plasma concentration of alanine (p = .004), glutamine (p < .001) and citrulline (p = .006).ConclusionsWe found an early depletion of plasma AAs’ concentration which partially recovered at day 6, which was unaffected by the route of nutrition.”

“The … indicated glutamine significantly reduced the length of … in the form of alanyl-glutamine (weighted mean difference [WMD], -3.17; 95% CI, -5.51 to -0.82; P = 0.008) and in … form of glycyl-glutamine (WMD, -3.40; 95% CI, -5.82 to -0.97; P = 0.006).”

“… glutamine dipeptide significantly reduced the length … in the form of alanyl-glutamine (weighted mean difference [WMD] = -3.84; 95% confidence interval [CI] -5.40, -2.28; z = 4.82; P < .001) … form of glycyl-glutamine (WMD = -5.40; 95% CI -8.46, -2.33; z = 3.45; P < .001).”

“The elevation of glutamine plasma levels by a perioperative intravenous infusion of l-alanyl-l-glutamine influenced the intracellular expression of IL-2 in the lower tertile only slightly.”

“In conclusion, administrations of Ala-Gln , parenteral or enteral, resulted in an increased plasma glutamine response, as compared with baseline.”

“Infusion of alanylglutamine significantly (P less than .01) increased arterial plasma concentrations of free alanine (260 +/- 31 v 330 +/- 38 mumol/L) and free glutamine (620 +/- 66 v 764 +/- 65 mumol/L) when compared with the baseline period.”