Possible Interaction: Glutamic Acid and Calcium Supplement

“Additionally, the same calcium ions are observed to coordinate with neighboring γGlu , better shielding their negative charges and in turn stabilizing these systems more than do the singly coordinating calcium ions observed in the case of nOcn.”

“As a result, excess glutamic acid causes overactivation of glutamate receptors and raises intracellular Ca 2 + concentration.”

“Excessive stimulation of this type of receptor by glutamic acid or NMDA agonists leads to a massive influx of calcium ions into the neuron followed by activation of a variety of calcium-dependent enzymes, impaired mitochondrial function, and the generation of free radicals.”

“The experiments evidence that 30-min preincubation of platelet membranes with 1 mM L-glutaminic acid produces inhibition of cAMP-induced activation of Ca , Mg-ATPase returning the activity of the enzyme to baseline levels.”

“Chloride and acetate salts of sodium, potassium, and calcium reduced the detection and recognition thresholds of L-glutamic acid but had no effect sodium glutamate thresholds.”

“The enzymes glutamic oxaloacetic transaminase and glutamic pyruvic transaminase produce glutamic acid which retards calcium oxalate crystallization.”

“Both Meth and Glu induced a rapid increase in Ca++i , which was blocked by MK801, suggesting that Meth enhanced Ca++i through Glu receptor in neurons.”

“The replacement of the aspartic acid present in the 12th position (-Z coordinating position) of the metal binding loop with a glutamic acid increases calcium affinity and abolishes magnesium binding, rendering the site calcium-specific.”

“On the other, the addition of Ca2+ ions significantly inhibited [3H]…-dependent manner at concentrations of above 2.5 mM. Calcium ions were also effective in significantly potentiating potencies to displace [3H]KA binding of … and CNQX, with concomitant reduction of those of agonists including KA, QA and Glu.”

“A high dietary content of calcium (25.9 vs 11.8 g/kg) reduced chick performance and the digestibility of glutamic acid , leucine and phenylalanine but increased the digestibility of lysine and histidine.”