Possible Interaction: Glutamate and Rosuvastatin

“In summary, three-day RST pretreatment induces resistance to the excitotoxic effect of L-glutamate in cultured neurons apparently by a mechanism that is independent of 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase inhibition.”

“ L-glutamate (200 microM, 1h) reduced neuronal viability (% of naive …+/-2% to 60+/-1%*, but pretreatment with RST (0.5 microM, 3 days) increased survival to 88+/-2%*. RST-induced neuroprotection was not affected … of mevalonate fully prevented the neurotoxic effects of a high dose (20 microM) of RST.”