Possible Interaction: Glucose and Vitamin K

“ Glucose (25 mM) added to the cell suspensions partially protected these cells from menadione action.”

“Using the process of glucose-stimulated insulin release by rat pancreatic islets as an index of alloxan cytotoxicity, we observed that the protective action of D-glucose was suppressed by D-mannoheptulose and menadione , impaired by NH4Cl, and little affected by aminooxyacetate.”

“The effects of glucose were concentration-related and were inhibited by mannoheptulose and menadione.”

“The 32P response to glucose was slightly decreased in the absence of extracellular Ca2+ or HCO3-, markedly impaired in the absence of K4, and virtually abolished in the presence of menadione (10 mumol/l).”

“ Menadione (2-methyl-1,4-naphthoquinone) inhibits insulin release evoked in the rat endocrine pancreas by glucose or glyceraldehyde, but fails to affect the secretory response to Ca2+, Ba2+, theophylline or gliclazide.”

“ Menadione affects both the early and late phase of the secretory response to glucose.”

“ Menadione also antagonizes in a dose-related fashion the ability of glucose to reduce 86Rb efflux, to provoke 86Rb accumulation, to cause biphasic changes in 45 Ca efflux and to stimulate 45 Ca net uptake in pancreatic islets.”

“Since, in the presence of glucose 11.1 mM, menadione 10 micrometer also severely decreases glucose-stimulated45 calcium net uptake and subsequent insulin release, it is concluded that the availability of reduced pyridine nucleotides may play an essential role in the secretory sequence by coupling metabolic to cationic events.”

“ Menadione markedly stimulates apparent uptake of glucose but has no effect on mannitol.”

“In conclusion, vitamin K possibly improves glucose and lipid metabolism and could be an emerging target in the context of prevention and control of T2DM, insulin resistance, and dyslipidemia.”

“Respiration of Saccharomyces cerevisiae in the presence of glucose is inhibited by concentrations of 2-methyl-1,4-naphthoquinone (K3 ) and 2-methyl-4-aminonaphthol hydrochloride (K5) of the magnitude of 200–500 μg./ml.”