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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Glucose
supplement:
Vitamin B 6
Research Papers that Mention the Interaction
“RNAi-mediated silencing of PDXK in human cells or treatments with PLP inhibitors resulted in chromosome breakage, which was potentiated by glucose and reduced by ALA.”
Sugar and Chromosome Stability: Clastogenic Effects of Sugars in Vitamin B6-Deficient Cells“Ingestion of glucose is associated with a decrease in both circulating plasma PLP and TB6; therefore, carbohydrate ingestion should be considered when plasma PLP and TB6 concentrations are used to evaluate vitamin B-6 status.”
“These results suggest that PLP protects neurons from glucose deprivation‐induced damage by enhancing the formation of energy‐yielding products and relieving extracellular load of glutamate.”
Protective Effects of Pyridoxal Phosphate Against Glucose Deprivation‐Induced Damage in Cultured Hippocampal Neurons“It appears that PLP becomes firmly attached to the protein and that this binding is enhanced in the presence of glucose or galactose.”
“ Glucose causes a change in the molecular ellipticity in the pyridoxal-5'-phosphate region.”
“Sucrose as well as acceptor substrates, glucose and dextran protected the enzyme against inactivation by PLP.”
Chemical modification of dextransucrase from Leuconostoc mesenteroides NRRL B‐512F by pyridoxal 5′‐phosphate: Evidence for the presence of an essential lysine residue at the active site“In addition, pyridoxal-5-phosphate markedly reduced the rate of acid production by intact S. mutans cells from sucrose or glucose substrates.”
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