Possible Interaction: Glucose and Vincristine

“On testing the local effect of cytostatics, the drugs were dissolved in the perfusion solution, cyclophosphamide at a concentration of 10(-4) M and vincristine at 10(-6) M. Glucose absorption was not reduced by cyclophosphamide, while it was significantly reduced by vincristine.”

“Therefore, in the intact rat, prior exposure to glucose but not arginine protected the beta-cell from the inhibitory effect of vincristine on glucose-induced insulin release.”

“The addition of glucose to the medium partially reverses the effect of vincristine and completely reverses the stimulatory effect of sodium azide on the net uptake of methotrexate.”

“The similarity between the effects of vincristine and metabolic poisons … uptake and the partial reversal of the effect of vincristine … glucose suggest that this agent enhances methotrexate uptake by the inhibition of cellular energy metabolism … consequent inhibition of an energy-dependent process which limits methotrexate accumulation within the cell.”

“Addition of glucose to the medium resulted in a small, but significant, decrease in the inhibitory effects of both vincristine and colchicine.”