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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Glucose
drug:
Vinblastine
Research Papers that Mention the Interaction
“The initial rate of vinblastine uptake was reduced approximately 5-fold by glucose feeding of ATP-depleted wild-type (MDR1-G185) cells but was only halved in MDR1-V185 transfectants.”
Kinetic evidence suggesting that the multidrug transporter differentially handles influx and efflux of its substrates.“Restoration of ATP levels to near control values by addition of glucose also had opposite effects on the two cell lines, causing further accumulation of VLB by the sensitive line but leading to apparent drug efflux from the resistant line.”
“Disruption of the microtubular system with vinblastine or stabilization of microtubules with deuterium oxide inhibited the induction of granule movement by glucose.”
Cinemicrographic studies on beta granule movement in monolayer culture of islet cells.
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