Possible Interaction: Glucose and Vildagliptin

“To further elucidate these findings, the authors show that the insulin secretory response to glucose is enhanced with vildagliptin treatment not only by oral load but also after iv load, contributing to the numerical similarity of the calculated incretin effects.”

“ Vildagliptin also significantly decreased the standard deviation of the mean glucose (SD) and the mean of the daily differences (MODD) (p = 0.007 and 0.030).”

“There were significant interactions between the rate of ID glucose and VILD treatment on plasma glucose, intact and total GLP-1, and GIP (P < .05 for each) but not insulin, C-peptide, or glucagon.”

“ Vildagliptin improves the sensitivity of the alpha cell to glucose in patients with T2DM by enhancing the alpha-cell responsiveness to both suppressive effects of hyperglycaemia and stimulatory effects of hypoglycaemia.”

“ Vildagliptin also inhibits hepatic glucose production, mainly through changes in islet hormone secretion, and improves insulin sensitivity, as determined with a variety of methods.”

“ Vildagliptin treatment improves β‐cell sensitivity to glucose , producing increased insulin secretory rate relative to glucose in both postprandial and fasting states.”

“ Vildagliptin is a new oral antidiabetic agent that enhances pancreatic islet cell responsiveness to glucose.”

“ Vildagliptin is a dipeptidyl peptidase-IV inhibitor, which improves glycaemic control by increasing pancreatic beta cell responsiveness to glucose and suppressing inappropriate glucagon secretion.”

“Importantly, when the P/C was expressed in relation to the glucose stimulus (i.e., … fasting glucose and glucose AUC(0-240 min), respectively), the P/C relative to glucose was significantly … with vildagliptin vs. placebo, both in the fasting state (p=0.023) and postprandially (p=0.004).”

“Moreover, vildagliptin significantly decreased serum levels of glucose and lipids (except high density lipoprotein) together with brain MDA, TNF-α, serum DPP-IV activities and NF-κB/p65 gene expression.”