Possible Interaction: Glucose and Verapamil

“In groups 1 and 2, verapamil improved the tolerance for oral glucose , whereas the insulin response remained unaffected.”

“ Verapamil was further shown to inhibit the stimulatory effect of glucose on IAPP mRNA levels.”

“ Verapamil significantly inhibited the acute insulin response (AIR, mean change from 3–10 min) to glucose (5 g), as well as the AIR and AGR (acute glucagon response) to arginine (5 g).”

“ Verapamil , infused into normal subjects for different periods of time before the iv administration of glucose was ineffective in inhibiting the rapid release of insulin, even when it was infused for 1 h before the glucose stimulus was applied.”

“Intravenous infusion of verapamil , an organic antagonist of calcium transport into cells, produced a marked and significant inhibition of glucose- , glucagon- and sulfonylurea-induced increases in serum insulin in normal subjects.”

“In the thyrotoxic group, verapamil induced a significant fall in glucose from 60 min on, whereas it had no significant effect on the concomitant insulin concentration.”

“Inhibition of insulin secretion with the Ca(2+) channel blocker verapamil , the ATP-sensitive K(+) channel opener diazoxide, or the alpha(2)-adrenergic agonist clonidine blocked the effects of glucose on L-PK gene transcription.”

“ Verapamil had no significant effects on serum biochemistry, but caused a significant increase in serum potassium level and significant reductions in the rates of intestinal absorption of glucose and calcium.”

“ Verapamil toxicity increased arterial glucose from 3.5 +/- 0.16 to 6.1 +/- 1.1 mM; simultaneously, myocardial glucose extraction doubled, although endogenous insulin concentrations did not increase.”

“In the presence of glucose , both acetylcholine (ACh) and carbachol (CCh) produced a sustained increase in the rate of insulin release which was blocked by EGTA or verapamil.”