Possible Interaction: Glucose and Valproic Acid

“Therefore, it might be suspected that VPA therapy is associated with increased glucose stimulated pancreatic secretion and thus a higher body weight in the VPA group.”

“Several reports have pointed out the possible negative impact of valproate on glucose and insulin metabolism and particularly on body weight.”

“Objective: We hypothesized that treatment with VPA would improve the regulation of glucose and atherogenic dyslipidemia through reduction in circulating corticosterone.”

“In hearts perfused with palmitate, VPA (1 mmol/L) strongly inhibited the oxidation of pyruvate and lactate but slightly stimulated the oxidation of glucose.”

“In addition, VPA strongly inhibited glucose production from pyruvate.”

“The rate of lipid synthesis from lactate and 3-hydroxybutyrate, but not from glucose , was decreased significantly by 1 mM valproate.”

“ Valproate did not affect sterol synthesis but slightly enhanced phospholipid synthesis from glucose.”

“Elimination clearance of VPA was significantly higher (median 31%, p = 0.002) with glucose infusion as compared with fasting but was unchanged by clofibrate pretreatment as compared with control.”

“ Valproate markedly stimulated glutamine removal as well as the … of ammonia, aspartate, pyruvate, lactate, alanine and glucose ; the increase in ammonia formation was explained by a stimulation by valproate of flux not only … glutaminase (EC 3.5.1.2) but also through glutamate dehydrogenase (EC 1.4.1.3).”