Possible Interaction: Glucose and Uridine

“The plasma concentration of uridine increased by 21%, 25%, and 20% 30, 60, and 90 minutes after administration of glucose , respectively.”

“Furthermore, uridine affected the levels of 10 fatty acids, lipid and glucose gene (FASN, LCAT, PC, PEPCK, GSK3β, and GLUT2; P < .05) depending on the timing of administration (P < .05).”

“Moreover, uridine supplementation also affected glucose and lipid homeostasis in previous studies; however, the mechanisms remain unclear.”

“Greater reductions in the rates of glucose infusion (∼53%), glucose uptake (∼43%), and glycogen synthesis (∼60%) were observed with the addition of uridine.”

“ Glucose at concentrations between 4 and 24 mM caused a progressive increase in RNA labelling from [3H] uridine.”

“ Uridine in concentrations of 10(-4) to 10(-6) M stimulated the uptake of glucose and increased the content of glycogen, but had no effect on the production of lactate.”

“Conversely, in the absence of virtually all protein synthesis, glucose is still capable of stimulating incorporation of uridine into RNA.”

“ Glucose also stimulated the uptake and phosphorylation of uridine and increased the islet UTP pool size, but under the conditions of these studies the relative specific activity of the UTP pool was the same at 2.8 or 16.6 mm glucose.”