Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: Glucose and Troglitazone

supplement:

Glucose

Research Papers that Mention the Interaction

Troglitazone reduced integrated glucose and insulin responses to oral glucose by 10% (P = 0.03) and 39% (P = 0.003), respectively.
The Journal of clinical investigation  •  1997  |  View Paper
We conclude that the ability of troglitazone to upregulate adipocyte glucose transport, GLUT4 expression, and insulin signaling can contribute to its greater effect on whole-body glucose disposal.
Diabetes  •  2002  |  View Paper
The mean rate of glucose disposal increased by 54 percent during troglitazone therapy (P=0.006) and 13 percent during metformin therapy (P= 0.03 for the comparison within the group and between groups).
The New England journal of medicine  •  1998  |  View Paper
CONCLUSIONS The glycemic response after a glucose load is statistically and clinically significantly improved for patients with IGT treated with troglitazone.
The glucose , insulin, and C-peptide responses after a glucose load were significantly reduced at 6 and 12 weeks in the troglitazone treatment group.
Diabetes Care  •  1997  |  View Paper
Troglitazone treatment increased basal glucose transport 1.5- to 2.0-fold, whereas insulin-stimulated uptake was unaffected.
Endocrinology  •  1996  |  View Paper
Basal glucose uptake as well as both basal and insulin-stimulated glycogen synthesis increased approximately 1.6- and approximately 2.5-fold after chronic TGZ treatment, respectively.
Biochemical and biophysical research communications  •  2001  |  View Paper
Cell-line and animal models indicate that troglitazone may decrease hepatic glucose output by decreasing the rate of gluconeogenesis in the liver or by increasing glycolysis.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists  •  1998  |  View Paper
Troglitazone and Met significantly reduced the medium glucose and testosterone concentrations to levels comparable to those in Con cells.
Fertility and sterility  •  2009  |  View Paper
Troglitazone stimulates both glucose , and glibenclamide-induced insulin release at a concentration of 10−6 mol/l in these cells but, conversely, inhibits insulin secretion at 10−4 mol/l.
Diabetologia  •  2006  |  View Paper
Interestingly, interfering with troglitazone-induced activation of AMPK by decreasing the expression of the enzyme using siRNA inhibited the stimulation of 2-deoxyglucose uptake by the TZD.Conclusions/interpretationWe propose that troglitazone acutely increases glucose flux in muscle via an AMPK-mediated increase in glucose phosphorylation.
Diabetologia  •  2005  |  View Paper
Show More