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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Glucose
drug:
Trimetazidine
Research Papers that Mention the Interaction
“…,TMZ significantly lowered liver enzymes (ALT, AST) at 6 days ([29.0 ± …] vs. [69.2 ± 70.0]; two‐tailed p = 0.000), lowered glucose after 6 days ([6.80 ± 2.12] vs. [7.59 ± 2.24]; p = … ([58.4 ± 8.6] vs. [54.9 ± 8.4]; p = 0.008).”
The effect of trimetazidine treatment in patients with type 2 diabetes undergoing percutaneous coronary intervention for AMI“ TMZ decreased diastolic tension in both glucose- and in palmitate-perfused hearts.”
Adverse effects of free fatty acid associated with increased oxidative stress in postischemic isolated rat hearts“However, trimetazidine reduced glycolysis by ∼30% but did so only in hypertrophied hearts, an unexpected novel action of this agent that resulted in a larger fractional oxidation of glucose , effectively normalizing it in hypertrophied hearts.”
“ Trimetazidine also reduced the levels of free fatty acid, ketone bodies, lactic acid, and increased glucose and pyruvate levels in myocardial tissues.”
Trimetazidine Ameliorates Myocardial Metabolic Remodeling in Isoproterenol-Induced Rats Through Regulating Ketone Body Metabolism via Activating AMPK and PPAR α
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