Possible Interaction: Glucose and Triiodothyronine

“However, the observed increases in muscle and WAT glucose uptake support the proposed mechanism that liothyronine increases tissue glucose uptake.”

“In addition, we have shown that T3 modulates in vitro neuron membrane properties with the balance of inward glutamate ligand-gated channels currents and decreases synaptotagmin levels in conditions of deprived oxygen and glucose.”

“Androstanolone, human and bovine growth hormone, triiodothyronine and thyroxine only exerted such effect in the presence of 8 mM glucose.”

“ T3 correlated positively and significantly with waist circumference (p=0.004), glucose (p= 0.002), total cholesterol ( p=0.001) and LDL- cholesterol ( p<0.001 ) and negatively with body mass index ( p<0.001 )and triglyceride ( p=0.026).”

“This is not surprising because T3 regulates energy metabolism and thermogenesis and plays a critical role in glucose and lipid metabolism, food intake, and the oxidation of fatty acids (4).”

“In diabetics there was a significant negative relationship was observed between glucose and T3 (r=−0.491; p<0.001).”

“Addition of glucose and tri-iodothyronine ( T3 ) improved productivity, and the maximal productivity of pro-UKS1 was 67 μg ml−1 day−1.”

“The findings suggest that T3 regulates insulin level in the circulation after glucose ingestion and the increase in serum T3 levels after glucose ingestion is necessary for the glucose removal from the circulation in humans.”

“After a 75-g glucose load , splanchnic glucose output was enhanced by T3 by 30% (43.4 +/- 2.2 vs. 56.9 +/- 6.6 g/150 min; P less than 0.05), whereas arterial plasma concentrations of glucose, insulin, and C-peptide were not significantly different.”

“It is concluded that in healthy humans, exposure to elevated plasma concentrations of T3 increases the amount of glucose to be released from the splanchnic bed.”

“The data indicate that a pharmacologically induced rise in T3 , to levels comparable to those seen in hyperthyroidism, results in enhanced glucose production , with an increase in glucose uptake by the forearm.”