Possible Interaction: Glucose and Trifluoperazine

“CPZ, trifluoperazine , prochlorperazine, promazine and promethazine were found to inhibit glucose exit approximately in the order of their chemotherapeutic potency.”

“In addition, inhibitors of protein phosphatase 2B, deltamethrin (50 nm) and trifluoperazine (10 μm), caused partial reversal of Ca2+-dependent inhibition of d-glucose uptake.”

“ TFP (15 mumol/l), whereas inducing 50% inhibition of second-phase insulin release, totally suppressed the cAMP response to glucose and the accompanying first-phase insulin secretion (5-min incubations); these effects of TFP could be partially reversed by isobutyl methylxanthine (IBMX).”

“ Trifluoperazine slightly decreases but fails to abolish the effect of glucose.”

“Despite the fact that 10 μM trifluoperazine virtually abolished insulin release in response to 27.5 mM glucose , no effect on glucose-induced islet cyclic AMP increases were noted.”

“Both phases of insulin release in response to 16.7 mM glucose were inhibited by approximately 60% in the presence of 10 μM trifluoperazine when the latter was added 35 min prior to high glucose.”

“Moreover, in Ca2+ deprived medium (with no possibility for Ca2+ uptake) insulin release in response to glucose + ouabain or in response to veratridine was also inhibited by trifluoperazine.”

“Insulin release stimulated by glucose (20mm) was markedly inhibited by 10mum-trifluoperazine or -prochlorperazine and further inhibited at a concentration of 20mum.”

“It was also found that although trifluoperazine inhibited the effect of glucose to stimulate insulin release, it did not affect the synergism between glucose and 3-isobutyl-1-methylxanthine to potentiate insulin release.”