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Journal of the renin-angiotensin-aldosterone system : JRAAS • 2000 | View Paper
“In vitro, tolrestat inhibited in dose-dependent fashion the AR from bovine lenses (IC50, 3.5 X 10(-8) mol/L) and the formation of sorbitol in human RBC incubated with glucose (IC50, 3 X 10(-8) mol/L).”
Metabolism: clinical and experimental • 1985 | View Paper
“Raising the medium glucose to 30 mmol/l inhibited the angiotensin II and norepinephrine evoked increases in (Na+, K+)-ATPase activity, and this was prevented when tolrestat (10 μmol/l) was added or the myo-inositol content of the medium was raised from 70 to 500 μmol/l.”
“Significant inverse correlations existed between the concentration of Tolrestat and the phosphorylation rate of glucose of rabbit lens and optic nerve.”
“ Tolrestat completely inhibited the production of sorbitol in cells exposed to a high concentration of glucose but failed to protect the cells from glucose toxicity.”