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Last Updated: 3 months ago

Possible Interaction: Glucose and Tolrestat



Research Papers that Mention the Interaction

The stimulatory effect of glucose (25 mM) was blocked by insulin and tolrestat (an inhibitor of aldose reductase).
Tolrestat also inhibited the increase of cellular DAG and PKC activity stimulated by 25 mM glucose.
Journal of the renin-angiotensin-aldosterone system : JRAAS  •  2000  |  View Paper
In vitro, tolrestat inhibited in dose-dependent fashion the AR from bovine lenses (IC50, 3.5 X 10(-8) mol/L) and the formation of sorbitol in human RBC incubated with glucose (IC50, 3 X 10(-8) mol/L).
Metabolism: clinical and experimental  •  1985  |  View Paper
Significant inverse correlations existed between the concentration of Tolrestat and the phosphorylation rate of glucose of rabbit lens and optic nerve.
Journal of diabetes and its complications  •  1999  |  View Paper
These stimulatory effects of D(+)-glucose (25 mM) were blocked by an inhibitor of aldose reductase, Tolrestat.
Kidney international  •  1999  |  View Paper
Tolrestat completely inhibited the production of sorbitol in cells exposed to a high concentration of glucose but failed to protect the cells from glucose toxicity.
Diabetes  •  1994  |  View Paper