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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
Research Papers that Mention the Interaction
“The stimulatory effect of glucose (25 mM) was blocked by insulin and tolrestat (an inhibitor of aldose reductase).”
“ Tolrestat also inhibited the increase of cellular DAG and PKC activity stimulated by 25 mM glucose.”
Molecular mechanism(s) of insulin action on the expression of the angiotensinogen gene in kidney proximal tubular cells“In vitro, tolrestat inhibited in dose-dependent fashion the AR from bovine lenses (IC50, 3.5 X 10(-8) mol/L) and the formation of sorbitol in human RBC incubated with glucose (IC50, 3 X 10(-8) mol/L).”
“Raising the medium glucose to 30 mmol/l inhibited the angiotensin II and norepinephrine evoked increases in (Na+, K+)-ATPase activity, and this was prevented when tolrestat (10 μmol/l) was added or the myo-inositol content of the medium was raised from 70 to 500 μmol/l.”
“Significant inverse correlations existed between the concentration of Tolrestat and the phosphorylation rate of glucose of rabbit lens and optic nerve.”
“These stimulatory effects of D(+)-glucose (25 mM) were blocked by an inhibitor of aldose reductase, Tolrestat.”
“ Tolrestat completely inhibited the production of sorbitol in cells exposed to a high concentration of glucose but failed to protect the cells from glucose toxicity.”
The Effect of Aminoguanidine and Tolrestat on Glucose Toxicity in Bovine Retinal Capillary Pericytes
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