Possible Interaction: Glucose and Tolbutamide

“In the presence of glucose , the PLC-linked Ca(2+) signals were enhanced by tolbutamide (3-300 microM) and inhibited by diazoxide (10-100 microM).”

“In the presence of glucose, tolbutamide potentiated and diazoxide inhibited AVP- or bombesin-induced insulin secretion from HIT-T15 cells.”

“Glipizide (10-100 muM) AND TOLBUTAMIDE (400 MUM) inhibited the stimulatory effect of glucose , dbcAMP, and theophylline on [3H]leucine incorporation into IRI.”

“These observations suggest that tolbutamide decreases the release of glucose from the liver, while a t the same time increasing the over-all glucose utilization by that tissue.”

“Additionally, strong genetic correlations were found between measures of beta cell response after glucose and tolbutamide stimulation, with correlation coefficients ranging from 0.77 to 0.88.”

“ tolbutamide or kept within normal limits by a concomitant glucose infusion.”

“c) 500 mg tolbutamide by the oral route reduced the blood sugar level during the first and second hour following administration of 75 mg glucose substantially more in patients with glucose intolerance.”

“ Tolbutamid and glibenclamid treatment significantly improves the diabetic taste for glucose , both for detection threshold (DT) (p less than 0.01) and recognition threshold (RT) (p less than 0.001).”

“When plasma glucose levels were maintained by means of a concomitant variable glucose infusion during tolbutamide , the insulin responses to both isoproterenol and arginine were enhanced (isoproterenol: ΔAIR = +55 ± 15 μU/ml, n = 6, P < 0.001; arginine: ΔAIR = +137 ± 34 μU/ml, n = 8, P < 0.001).”

“Since glucose exerted synergistk effects on insulin release in-duced by the other insulinagogues (arginine, glucagon, and tolbutamide ), the insulinogenic effect of these insulinagogues In the presence of epinephrine was compared with their effect under hyperglycemie conditions similar to those obtained with epinephrine alone.”

“Pretreatment of the subjects with a glucose infusion enhanced also the insulin responses to glucagon and to tolbutamide , given intravenously 50 min later.”