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Last Updated: 4 months ago

Possible Interaction: Glucose and Tolbutamide



Research Papers that Mention the Interaction

Additionally, strong genetic correlations were found between measures of beta cell response after glucose and tolbutamide stimulation, with correlation coefficients ranging from 0.77 to 0.88.
Diabetologia  •  2014  |  View Paper
Exposure for 18 h to 100 µM tolbutamide or glibenclamide significantly impaired insulin release in response to glucose and a broad range of insulin secretagogues.
Diabetes, obesity & metabolism  •  2010  |  View Paper
Finally, HGP fell by 26.3 ± 6.0 % at 10 min after a dose of tolbutamide that elevated both peripheral and portal insulin concentrations, at a time when HGP had barely increased (Δ = + 6.9 ± 5.3 %).
The … tolbutamide … HGP (from 9.0 ± 0.5 to 7.7 ± 0.5 µmol · kg-1 · min-1 or Δ = -13.8 ± 4.5%; p < 0.… 5.1 ± 0.2 to 4.4 ± 0.1 mmol/l or Δ = -13.0 ± 2.1%; p < 0.01 compared to saline).
Diabetologia  •  1997  |  View Paper
Tolbutamid and glibenclamid treatment significantly improves the diabetic taste for glucose , both for detection threshold (DT) (p less than 0.01) and recognition threshold (RT) (p less than 0.001).
Revue roumaine de physiologie  •  1990  |  View Paper
The decrease of plasma glucose within 60 min after tolbutamide injection was more than 20% of the basal level in eight of nine Type II diabetics, and in all of seven Type
Experimental and clinical endocrinology  •  1988  |  View Paper
The decrease in plasma glucose following intravenous tolbutamide was significantly less in patients than in controls (p less than 0.05) despite insulin levels which were greater than in controls (p less than 0.05).
Hormone research  •  1985  |  View Paper
Thus, tolbutamide increases the AIR of nonglucose stimuli, but this augmentation by tolbutamide is blunted by the concomitant decrease in plasma glucose.
Diabetes  •  1982  |  View Paper
We conclude that tolbutamide augments the insulin response to nonglucose stimuli.
When plasma glucose levels were … means of a concomitant variable glucose infusion … tolbutamide , the insulin responses to both isoproterenol and arginine were enhanced (isoproterenol: delta AIR = +55 +/- 15 microU/ml, n = … less than 0.001; arginine: delta AIR = +137 +/- 34 microU/ml, n = 8, p less than 0.001).
Diabetes  •  1980  |  View Paper
Insulin levels 30 min after oral glucose in TGTT was significantly lower in diabetics than in the normal subjects.
When 50 g glucose was ingested 60 min after the injection of 1 g tolbutamide ( TGTT ), insulin response in diabetics rather decreased.
The Tohoku journal of experimental medicine  •  1974  |  View Paper
The disappearance rate of intravenously injected glucose and both early and delayed insulin responses to the glucose were enhanced to a much greater degree in the morning than in the evening by the simultaneous intravenous injection of tolbutamide.
Diabetes  •  1973  |  View Paper
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