Possible Interaction: Glucose and Tissue Plasminogen Activator

“Downregulation of PKC by preincubation with TPA for 24 hours also abolished the effect of glucose and TPA on endothelial cell permeability.”

“Plasma fibrinolytic potential is reduced in NIDDM and it is known that glucose and insulin can modulate plasminogen activator inhibitor (PAI-1) and tissue-plasminogen activator (t-PA) secretion and can therefore regulate local fibrinolysis.”

“Accordingly, in vivo positron emission tomography studies with 18-… mice overexpressing tPA in neurons show that neuronal tPA induces … of glucose in the ischemic brain and that this effect is associated with a decrease in … of the ischemic lesion and improved neurological outcome following the induction of ischemic stroke.”

“Culturing in TPA slightly improved the insulin secretory response to 15 mM glucose compared with control-cultured islets; however, sustained rates of 15 mM glucose-induced secretion from these islets were significantly less than the responses of freshly isolated islets.”

“Pharmacological activation of protein kinase C with the phorbol ester TPA in the presence of 5 mM glucose increases microvascular albumin clearance and blood flow, and similar effects are observed with 1-monoolein (MOG), a pharmacological inhibitor of the catabolism of endogenous DAG.”

“Insulin release from the perfused pancreas was markedly augmented by 20 nM TPA in the presence of 4.4 mM glucose in pregnant rats, but not in nonpregnant rats.”

“Addition of forskolin or TPA to the perifusion medium markedly amplified the response to glucose without causing a biphasic pattern of release.”

“Culturing in TPA slightly improved the insulin secretory response to 15 mM glucose compared with control-cultured islets; however, sustained rates of 15 mM glucose-induced secretion from these islets were significantly less than the responses of freshly isolated islets.”