Possible Interaction: Glucose and Thyroxine

“Androstanolone, human and bovine growth hormone, triiodothyronine and thyroxine only exerted such effect in the presence of 8 mM glucose.”

“More recent attempts to modify the course of this disease have involved the use of thyroxine (Koulischer and Pickering, 1956) and glucagon (Lowe et al., 1959) to influence the intermediary metabolism of glucose.”

“ Hepatic glucose appearance rates fell with fasting and increased significantly during T4 supplementation, but not to prefasting levels.”

“ Glucose area during oral glucose tolerance test was significantly correlated with the elevated thyroxine (r = 0.8, p less than 0.01), and triidothyronine (r = 0.66, p less than 0.05).”

“The daily intravenous administration of thyroxin to dogs causes a marked increase in the glomerular filtration rate, renal plasma flow, tubular transport of dextrose and p-aminohippurate and an increase in renal oxygen consumption.”

“However, serum concentrations of phosphorus, glucose , and alkaline phosphatase were higher in T4 hens as compared to their control counterparts.”

“administered daily for 7 days to levo‐thyroxine‐treated animals decreased the levels of serum thyroid hormones and glucose as well as hepatic glucose‐6‐phosphatase activity, demonstrating its potential to regulate hyperthyroidism and hyperglycemia.”

“ Thyroxine induces a selective inhibition of glucose induced insulin release which is reversed by pyruvate; this indicates that thyroxine interferes with the glycolysis in the beta cell.”

“We have shown that thyroxine activates the kidney glucose-6-phosphatase enzyme and the liver glucose 6-phosphate transport systems.”

“These data indicate that the increase in serum total and free T3 concentrations associated with glucose feeding reflects augmented total body T3 production from T4.”