Possible Interaction: Glucose and Thyrotropin-Releasing Hormone

“Total 24-h area under the curve (AUCtotal) glucose ] tended to be lower for TRF versus EXF (−5.5 ± 9.0 mmol/L/h, p = 0.09).”

“It was concluded that glucose directly modulates the effect of sauna on plasma TSH at a suprapituitary level, while the inhibiting effect of glucose on plasma rT3 response to sauna and TRH is probably mediated by the insulin effect on thyroid hormone metabolism.”

“ TRH infusion reduced serum glucose levels following oral glucose in all 6 subjects investigated.”

“ TRH thus has marked actions on gastro-intestinal function in man inhibiting and/or retarding the absorption of glucose and xylose from the gut.”

“infusion of TRH reduces serum levels of glucose following a peroral xylose load.”

“These data demonstrate that TRF improves cardiac glucose utilization and ameliorates cardiac dysfunction induced by simulated microgravity, at least partially, through restoring cardiac FGF21 signaling, suggesting TRF as a potential countermeasure for cardioprotection in long‐term spaceflight.”

“Of note, glucose also induced expression of TRH , suggesting that glucose might affect the hypothalamic-pituitary-thyroid axis via the regulation of hypothalamic CRE activity.”

“These findings significantly advance our knowledge about the impact of glucose on hypothalamic signaling and suggest that TRH release might account for the central anorexigenic effects of glucose and could represent a new molecular link between hyperglycaemia and thyroid dysfunction.”

“In contrast, glucose ingestion altered, by the third week, TRH content in amygdala, hippocampus, hypothalamus and nucleus accumbens, PPII activity in hippocampus and frontal cortex; by the sixth week, TRH content in amygdala and n. accumbens of male and females.”

“administration of TRH (3 nmol) caused small increases in plasma E and glucose at the C7-T1 vertebral level, but it did not change plasma E, NE and glucose levels at the sacral level.”

“ Glucose had no effect on TRH release in cultured fetal islets, but inhibited TRH release in adult islets.”

“Whereas the secretion of immunoreactive insulin and somatostatin by incubated rat islets is known to be dose-dependently stimulated by glucose, that of glucagon and TRH was inhibited by glucose.”

“Thyrotropin-releasing hormone, TRH , increases the plasma levels of glucagon, insulin, glucose and free fatty acids in rabbits.”