Possible Interaction: Glucose and Thiopental

“It was also shown, in the same publication, that thiopentone impairs the ability of the body to deal with an extra load of glucose.”

“We conclude that the thiopental‐induced isoelectrical condition in rat cortex significantly affected glucose contents by depressing brain metabolism, which remained substantial at isoelectricity.”

“We conclude that thiopentone provokes disturbances in glucose and serum NEFA metabolisms and abolishes the serum IRI response to hyperglycaemia.”

“ Thiopental (0.5 mM) induced an increase in input resistance of 12.7, 17.9 and 16.0% in 0, 5.6 and 11.1 mM glucose , respectively.”

“ Thiopental 0.2 and 1.0 mM increased by 16.6 and 33.3%, respectively, the insulin release induced by 6.0 mM glucose.”

“ Thiopental reduced the 86Rb efflux rate in both 0 and 6.0 mM glucose , but had only a slight effect in 16.7 mM glucose.”

“The data suggest that thiopental therapy improves distribution of brain blood flow and brain glucose uptake early post-ischemia and depresses CMROa later post-ischemia.”

“It is concluded that the duration of surgical anaesthesia with thiopentone can be prolonged by simultaneous intravenous administration of glucose , and this prolongation can be cut short at will by administration of drugs like physostigmine and bemegride.”

“Abstract The inhibitory action of uncoupling agents like 2:4-dinitrophenol, salicylate, thiopental and sodium oleate on the release of histamine from isolated rat diaphragm by compound 48 80 , is markedly decreased by glucose.”

“ Thiopental was found to inhibit the in vitro oxidation of glucose , lactate, and pyruvate but there was no difference in the degree of inhibition between control and tolerant mouse brain homogenates.”