Possible Interaction: Glucose and Thiamine

“… peak glucose improved from 69.0 ± 6.4% to 152.8 ± 22.9% in group H (p < 0.005), from 57.6 ± 12.6% to … (p < 0.005), and from 57.8 ± 8.3% to 167.8 ± 11.6% in group NIDDM (p < 0.005) following administration of thiamine.”

“ Thiamine , a well-known co-activator of pyruvate dehydrogenase complex, a gatekeeping enzyme, shifts energy utilization of glucose from glycolysis to oxidative phosphorylation.”

“ Thiamine supplementation increases lactate clearance without modifying renal function in mice with AKI, enhances glucose production by renal tubular cells ex vivo and is associated with reduced mortality and improvement of the metabolic pattern in a retrospective cohort of critically ill patients with AKI.”

“BACKGROUND The prevailing teaching in medical school curricula and in medical textbooks is that if thiamine deficiency is suspected, thiamine supplementation should be given before administering glucose.”

“In the southern region decreasing of level of glucose , calcium and increasing of lactate, pyruvate, fatty acids were detected under decreased provision of organism with thiamine.”

“ Vitamin B1 (or thiamine) plays a key role in energy production from glucose.”

“Conclusion/interpretationSupplementation with high-dose thiamine may prevent deterioration in fasting glucose and insulin, and improve glucose tolerance in patients with hyperglycemia.”

“If thiamine defi ciency is suspected, thiamine should be administered before a patient is given glucose.”

“Both thiamine and aminoguanidine corrected reduced pericyte viability when added to high D-glucose.”

“The fractional rate of de novo ribose synthesis from glucose is decreased several fold 2 to 4 days after removal of thiamine from the culture medium.”