Toxicity in vivo of different immunosuppressive drugs in fetal porcine pancreatic islets.

Perfusion experiments with graft-bearing kidneys of cyclosporine-treated animals showed a significantly decreased insulin secretion in response to

Survival of isolated human islets of Langerhans maintained in tissue culture.

Glucagon release from the cultured islets was reduced significantly by 16.7 mM glucose alone, but stimulated by

Glucose- and Metabolically Regulated Hepatic Insulin Gene Therapy for Diabetes

 in these animals augmented the secretion of human insulin, demonstrating metabolic modulation of insulin secretion in vivo.

Calcium antagonists and islet function

 in the absence of Ca2+ and Mg2+ is enhanced by 

, partially inhibited by verapamil, and abolished by the Ca2+-chelator EGTA.

Can desensitization of the B-cell to D-glucose be simulated in cultured pancreatic islets?

In the latter islets, the secretory response to

 (8.3 mM or more) was still modest, especially over short periods of incubation, but was markedly enhanced by either 

Effect of salicylate poisoning on insulin secretion. Studies on its mechanism of action

 (5, 10 and 15 mM) significantly increased the insulin secretion induced by 11 mM 

Glycogen accumulation in rat pancreatic islets

Glycogenolysis was observed, however, when the concentration of

 was decreased to 2.8 mM and, in such a case, was further enhanced by forskolin and 

Direct effects of progesterone on rat islets of Langerhans in vivo and in tissue culture

 (5 mmol/l), while their insulin content was not significantly different from control islets cultured for a similar period.

Ethanol influence on insulin secretion from isolated rat islets

 mediated insulin release from control islets but ethanol treatment produced a significant inhibition of insulin response.

Evidence for decreased sensitivity to glucose of isolated islets from spiny mice (Acomys cahirinus)

 5 mM, arginine 10 mM, and cytochalasin B 10 Μg/ml, all enhanced IRI release in the presence of 

 16.7 mM to a relatively greater extent fromAcomys than from rat islets.

Chromium-induced inhibition of insulin secretion from isolated Islets of Langerhans

 was employed to potentiate the stimulatory effect of 16.5 mmol/l 

, the inhibitory effect of 1.5 mmol/l Cr was reduced and that of 0.5 mmol/l Cr virtually abolished.

In vitro regulation of insulin release and biosynthesis of fetal rat pancreatic cells explanted on pregnancy day 16.

Cells that had initially been cultured for 2 days in 5 mmol/l

 showed an increased insulin release, when subsequently cultured in 15 mmol/l glucose for 24 h. 

 potentiated the response and caused a decrease in cellular insulin content.

Cryogenic storage of isolated, purified porcine pancreatic islets.

, the secretion of the hormone peaked to 221 +/- 83 (control islets) and 479 +/- 140 pmol/L (cryopreserved islets, P = 0.1).

Correlation between Ca(2+)-ATPase activity of rat islet cells and insulin secretion.

 (10 mmol/l), ACTH (0.11 nmol/l), bovine GH (0.46 mumol/l), prolactin (0.2 mumol/l) or ….0 nmol/l) have significantly lower Ca(2+)-ATPase activity than those preincubated with only 3.3 mmol glucose/l.

Persistent Reversal of Diabetes by Transplantation of Fetal Pig Proislets Into Nude Mice

During culture, fetal proislets showed no insulin response to glucose alone but a significant response to

Value of in vivo electrophysiological measurements to evaluate canine small bowel autotransplants.

 stimulated potential difference responses were significantly less than the corresponding responses at day seven (p less than 0.05).

[Aggregates of islet cells, their structure and insulin-producing activity during cultivation in vitro].

They showed a good insulin-secreting capacity and were able to increase insulin release in response to

ADP and glucose as possible synergistic partners in the stimulation of liver glycogen synthase activation.

The effect of ADP appeared distinct from that of the methylxanthines since it was observed that at near saturating concentrations of ADP and of

, stimulation was increased by addition of 

Evidence for a role of microfilaments in insulin release from purified beta-cells.

Glucose alone failed to stimulate insulin release whereas

, cytochalasin D or B markedly potentiated insulin release.

Diazoxide unmasks glucose inhibition of insulin release by counteracting entry of Ca2+.

 restored the insulin secretory response to 

The effect of glucose on liver glycogen synthase phosphatase activity in the presence of ATP-Mg.

However, in vitro, certain methylxanthines such as caffeine or

 to approximately 10 mM, a concentration well within the normal range of liver glucose concentrations.

Interaction between D-glucose and Ca2+ in the priming of the pancreatic B-cell.

 in the final incubation medium minimized but failed to abolish the priming action of 

Effects of adenosine and adenosine analogues on glycogen metabolism in isolated rat hepatocytes.

, an R-receptor blocking agent, but not by nitrobenzylthioinosine or dipyridamol which are nucleoside transport inhibitors.

Regulation of RNA metabolism in relation to insulin production and oxidative metabolism in mouse pancreatic islets in vitro.

 maintained a high RNA content in the presence of 3.3 mM 

 also increased the islet RNA content when added together with 16.7 mM 

Dissociation between insulin secretion and DNA synthesis in cultured pancreatic islets.

 induced insulin release but lowered both 3H-Tdr synthesis and insulin content in the islets.

Glucose inhibits insulin release when not promoting the entry of calcium into the beta-cells.

Chloride Modulation of Insulin Release, 86Rb+ Efflux, and 45Ca2+ Fluxes in Rat Islets Stimulated by Various Secretagogues

 potentiated the insulinotropic effect of 

 more markedly at low CI− than at normal CI−, but did not restore a normal rate of 86Rb+ efflux.

Regulation of 86Rb outflow from pancreatic islets. IV. Effect of cyclic AMP, dibutyryl-cyclic AMP and theophylline.

 was suppressed by quinine, suggesting that it may result from an increase in cytosolic Ca2+ concentration.

Genetic regulation of galactokinase in Tetrahymena by cyclic AMP glucose, and epinephrine.

 is mimicked, in glycerol-grown cells, by the addition of millimolar amounts of dibutyryl adenosine 3':5'-cyclic monophosphate or phosphodiesterase inhibitors such as caffeine and 

Characterization of the uptake of the methylxanthines theophylline and caffeine in isolated pancreatic islets and their effect on D-glucose transport.

 in a dose-dependent manner and within the limits of the experimental system, this inhibition appeared to be non-competitive.

Insulin secretion. Interrelationships of glucose, cyclic adenosine 3:5-monophosphate, and calcium.

 at physiologic levels of extracellular calcium, both the first and second phases of secretion are prominent.

Abnormal secretion of insulin and glucagon by the in vitro perfused pancreas of the genetically diabetic Chinese hamster.

 together caused greater insulin release than either stimulant alone in both normals and diabetics; however, the diabetic response was still subnormal.

Defective insulin secretion in the N.Z.O. mouse: in vitro studies.

However, the N.Z.O. islets were more sensitive to arginine than the C57B islets, and their response to

Inhibition of Renal Gluconeogenesis by Theophylline 1

 from all these substrates but did not affect ATP levels in the renal tubule cell.

Summary Theophylline, at a concentration from 1.0–10.0 mM, significantly inhibited glucose production from glycerol, malate, pyruvate, and α-ketoglutarate by the isolated tubules of rat renal cortex; the higher the

 concentration in the incubation media the smaller the 

Paradoxical effects of theophylline and its interaction with insulin on glucose metabolism in adipose tissue.

 per ml to the incubation medium caused a large decrease in the conversion of 

 to fatty acids, glyceride glycerol, and CO2 and a large increase in lipolysis in tissue from both fed and fasted rats.

The ontogeny of insulin secretion mechanisms.

Glucose potentiated the action of theophylline on the foetal β cell and

The stimulus-secretion coupling of glucose-induced insulin release. XI. Effects of theophylline and epinephrine on Ca efflux from perifused islets.

 on the 45Ca efflux, suggesting that the sugar prevents the cationic outflow otherwise associated with theophylline-induced calcium redistribution.

Insulin Secretion Studied in the Perfused Rat Pancreas: II. Effect of Glucose, Glucagon, 3'5' Adenosine Monophosphate, Theophylline, Imidazole and Phenoxybenzamine; Their Interaction with Diazoxide

 stimulated additional insulin secretion, significantly higher than that produced by glucose alone.

On the regulation of glycogen metabolism in Tetrahymena.

 markedly increased the synthetase activity and decreased the phosphorylase activity.

Perifusion of rat pancreatic tissue in vitro: substrate modification of theophylline-induced biphasic insulin release.

 concentrations from 2.5 to 5, then 10 mM produced a progressive reduction in both indices of the secondary response, which was inversely related to the primary response.

Effect in vitro of theophylline and prostaglandin E1 on free fatty acid release and on triglyceride synthesis in rat adipose tissue.

Abstract Experiments in vitro , carried out on paired rat epididymal fat pads, show that

 increases free fatty acid release and decreases triglyceride synthesis from 

Effects of theophylline and catecholamines on lipolysis and glycogenolysis in vivo.

 pretreatment also significantly augmented the increase in lactic acid produced by E and, when given with NE, significantly increased 

The reversal of glucose repressed prodigiosin production inSerratia marcescens by the cyclic 3′5′-adenosine monophosphate inhibitor theophylline

 was found to cause severe repression of prodigiosin production inSerratia marcescens and a dose related partial reversal was demonstrated by 

Comparative studies on sporulation-promotive actions of cyclic AMP, theophylline and caffeine in Saccharomyces cerevisiae

 and caffeine promoted sporulation when added to a presporulation medium containing 

supp.ai

Discover Supplement-Drug Interactions

Possible Interaction: Glucose and Theophylline

Share:

Glucose

Theophylline

Research Papers that Mention the Interaction