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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Glucose
drug:
Tetrodotoxin
Research Papers that Mention the Interaction
“Consistent with this, TTX drastically reduces both transient and sustained insulin secretion in the presence of 5–6 mM glucose , but has little effect in 10 mM glucose, at which concentration cells rapidly depolarize to ≈ −35 mV, a Vm sufficient to rapidly inactivate Na+ and LVA Ca2+ currents.”
Voltage-dependent Na+ and Ca2+ currents in human pancreatic islet β-cells: evidence for roles in the generation of action potentials and insulin secretion“The conductance curve of TTXr Na(+) current shifted leftward after 24 h exposure to 45 mM glucose.”
In vitro hyperglycemia enhances sodium currents in dorsal root ganglion neurons: An effect attenuated by carbamazepine“The Na(+) channel antagonist tetrodotoxin (6 microM) significantly decreased glucose- and TsTx-V-induced insulin secretion (P<0.001).”
“The selective sodium-channel blocker tetrodotoxin (TTX, 1 microM) reduced glutamate release from deprivation of oxygen and D-glucose , while calcium-channel blockade was ineffective.”
“In the absence of external Ca2+, glucose still caused intracellular Ca2+ release, an effect blockable by tetrodotoxin.”
“ TTX significantly increased fluid uptake from normal intestines perfused with an isotonic electrolyte solution containing glucose while a considerably smaller effect was seen in intestinal segments perfused with a solution with mannitol.”
“The secretory responses to the neurotoxins, but not 15.3 mM glucose , were blocked by tetrodotoxin.”
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