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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“The main result of … study is that suramin has only an effect on HT29-D4 … growth and differentiation when the concentration of glucose is above 10 mM. Therefore the efficiency of suramin as an anticancer drug may be greater on poorly differentiated tumoral cells with a high proliferative capacity.”
The concentration of glucose in the culture medium determines the effect of suramin on the growth and differentiation of the human colonic adenocarcinoma cell clone HT29-D4.“In contrast to hepatocytes, in kidney-cortex tubules suramin augments glucose production and decreases lactate formation.”
Suramin-induced reciprocal changes in glucose and lactate synthesis in renal tubules contribute to its hyperglycaemic action.“ Suramin (50-200 microM), a purinoceptor blocker, reversibly and dose-dependently inhibited the rise in cytoplasmic calcium concentration ([Ca2+]i) induced by glucose and by ATP in single beta cells.”
“Furthermore, it was observed that the islet activity of the glucose producing glycogenolytic hydrolase, acid amyloglucosidase, which is excessively high in the obese mouse, was markedly reduced by suramin (about 70%) at 20 hr.”
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