Possible Interaction: Glucose and Sulforaphane

“Moreover, sulforaphane reversed the disease signature in the livers from diabetic animals and attenuated exaggerated glucose production and glucose intolerance by a magnitude similar to that of metformin.”

“ Sulforaphane suppressed glucose production from hepatic cells by nuclear translocation of nuclear factor erythroid 2–related factor 2 (NRF2) and decreased expression of key enzymes in gluconeogenesis.”

“ Sulforaphane , a natural compound identified by drug repurposing, reduces hepatic glucose production and improves glucose control in type 2 diabetes.”

“The authors showed that sulforaphane inhibits glucose production in cultured cells and improves glucose tolerance in rodents on high-fat or high-fructose diets.”

“This suggests that screening of compounds to counter senescence-associated glycolytic overload may be an effective strategy to identify compounds with antisenescence activity and health beneficial effects of SFN in longevity may involve delay of senescence through glucose and glycolytic restriction response.”

“In ob/ob mice, SFN improved glucose tolerance and reduced exaggerated glucose production.”

“Initially, 5-day-old whitetop seedlings were elicited … for 72 h. According to the results, sulforaphane formation … glucose , and was maximized with the concentrations of 166 and 250 mM. Consequently, 2-dimensional gel electrophoresis … was shown that 25 protein spots were differentially expressed between glucose-elicited seedlings and control.”