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“Increasing the in vitro glucose concentration of blood samples from both groups significantly increased the amount of acetylsulphamethazine produced.”
“ Sulphadimidine potentiated the effects of glucose and tolbutamide on insulin secretion, whereas phenylbutazone was found to augment glucose-stimulated insulin release and to antagonize the tolbutamide effect.”
“The presence of glucose , fructose, sucrose and meat extract exerted an inducing effect on SMZ degradation, resulting in removal efficiencies of 54, 53, 58 and 61%, respectively, indicating the occurrence of cometabolism.”