Possible Interaction: Glucose and Streptozocin

“However, single or double intracerebroventricular (icv) STZ injection(s) chronically decrease cerebral glucose uptake and produce multiple other effects that resemble molecular, pathological, and behavioral features of Alzheimer’s disease (AD).”

“In addition, kidney weight, serum creatinine and excreted amounts of urinary protein, glucose and DPP4 enzyme were enhanced by STZ.”

“Brief exposure of β‐cells to 2–2 mmol 1‐1 streptozotocin resulted in impairment of the response to glucose , manifested as disappearance of the cyclic variation of Ca2+i.”

“Streptozotocin STZ ) is often used to induce dysregulation of glucose and insulin metabolism in animal and cell culture models.”

“Intracerebroventricular administration of streptozotocin (ICV‐STZ) leads to glucose and energy metabolism dysfunction, cognitive impairment, and increased oxidative stress in the brain.”

“ STZ increased the glucose content , mRNA expression of glucose transporter 1 (GLUT1) and markers of oxidative stress in the head.”

“Results Our findings indicated that the administration of STZ significantly increased the serum concentrations of glucose , triglycerides, cholesterol, CRP, IL-6, TNF-a, and MDA and decreased the serum levels of GSH and TAS (P<0.05) in diabetic rats.”

“We observed that administration of streptozotocin caused a significant increase in plasmatic glucose and a decrease in insulin levels.”

“These results suggest that glucose plays a major role in modulating the rewarding effects of nicotine in male rats treated with STZ.”

“ STZ caused an elevation in the serum levels of glucose , MDA, IL-6, and TNF-α with reduction in the levels of GSH and TAS (P < .01).”