Possible Interaction: Glucose and Streptomycin

“The presence … and glucose, … streptomycin , as well as the observation that anaerobic bacteria are somewhat resistant to its activity, has suggested that special attention be paid to … to learn whether their effects are of a fundamental nature or are due to secondary factors such as fall in pH value.”

“The results suggest that streptomycin might inhibit the uptake and metabolism of glucose and decrease the ATP level in the inner ear tissues, and that the inner ear tissues accelerate the metabolism of amino-acids for compensation.(ABSTRACT TRUNCATED AT 250 WORDS)”

“Soluble vegetative protein was found to be the chief source of soluble inorganic phosphate, which when monitored along with dextrose addition boosted streptomycin production considerably.”

“Our strain had smooth spores as shown by the electron microscope, did not produce hydrogen … on which the culture was growing, hydrogen sulfide was definitely detected), was nonchromogenic, grew on D-glucose and D-xylose, but not on L-… surface of the colony, was inhibited by streptomycin with … before.”

“The Q o2 value for oxidation of glucose by organisms harvested when inhibition of growth by streptomycin is first detectable is lower, by about 20%, than that of normal organisms, and falls to c. 30% of normal when growth is fully inhibited.”

“The inhibiting effect of glucose upon streptomycin activity is due to the specific nature of the organic nitrogenous compounds in the medium and to the salt concentration.”