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Last Updated: 23 days ago

Possible Interaction: Glucose and Sorbinil

supplement:

Glucose

Research Papers that Mention the Interaction

At … 100 micron sorbinil , there was a 59% … accumulation in response to apical glucose (P = 0.004, N = 3 sorbinil vs. N = 4 controls) and a 66% inhibition in response to basolateral … = 0.008, N = 3 sorbinil vs. N = 4 controls) 48 hours after the addition of the inhibitor.
The increase in fibronectin concentration in response to glucose was inhibited by the aldose reductase inhibitor sorbinil.
Kidney international  •  1999  |  View Paper
Sorbinil dose-dependently reduced both intracellular sorbitol levels (79.8% reduction of 60 mmol/L D-glucose induced intracellular sorbitol with 100 micromol/L sorbinil (N = 3, P < 0.01) and glucose-induced TGF-beta 1 and MCP-1 secretion.
Kidney international  •  2003  |  View Paper
Under these experimental conditions, we can demonstrate polyol pathway activation, and furthermore the increase in fibronectin concentration in response to glucose was inhibited by the aldose reductase inhibitor sorbinil.
Nephron Experimental Nephrology  •  1999  |  View Paper
Exposure of hRPE cells to 20–40 mM glucose produced time- and dose-dependent increases in sorbitol content and decreases in myo-inositol content that were partially blocked by the aldose reductase inhibitor sorbinil.
Diabetes  •  1991  |  View Paper
The coadministration of sorbinil (0.1 mmol/l) to 40 mmol/l glucose partially prevented the inhibitory effect of glucose on myo-[3H]inositol uptake.
Investigative ophthalmology & visual science  •  1992  |  View Paper
The inhibition of myo-inositol uptake by cells chronically exposed to increased concentrations of glucose or galactose was due to a noncompetitive type of inhibition that was blocked by the addition of sorbinil.
Diabetes  •  1991  |  View Paper
The absolute rate of collagen synthesis, in proline molar terms, by pericytes in medium with 5 mM glucose was 3.3 +/- 1.… to 8.8 +/- 3.7 pmol 10(-7) cells 24 hr-1 when the glucose concentration was increased to 40 mM. Sorbinil (0.1 … of glucose , but ….
Experimental eye research  •  1985  |  View Paper
At a dose of 100&mgr;M sorbinil there was 59% inhibition of fibronectin accumulation in response to glucose , 48 h after the addition of the inhibitor (4.76 +/- 1.4 vs 11.53 +/- 1.41, mean +/- SD, p = 0.01, n = 3).
The increase in fibronectin concentration in response to glucose was inhibited by the aldose reductase inhibitor sorbinil.
Kidney international  •  1999  |  View Paper