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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
Research Papers that Mention the Interaction
“At … 100 micron sorbinil , there was a 59% … accumulation in response to apical glucose (P = 0.004, N = 3 sorbinil vs. N = 4 controls) and a 66% inhibition in response to basolateral … = 0.008, N = 3 sorbinil vs. N = 4 controls) 48 hours after the addition of the inhibitor.”
“The increase in fibronectin concentration in response to glucose was inhibited by the aldose reductase inhibitor sorbinil.”
Renal proximal tubular cell fibronectin accumulation in response to glucose is polyol pathway dependent.“ Sorbinil dose-dependently reduced both intracellular sorbitol levels (79.8% reduction of 60 mmol/L D-glucose induced intracellular sorbitol with 100 micromol/L sorbinil (N = 3, P < 0.01) and glucose-induced TGF-beta 1 and MCP-1 secretion.”
“Under these experimental conditions, we can demonstrate polyol pathway activation, and furthermore the increase in fibronectin concentration in response to glucose was inhibited by the aldose reductase inhibitor sorbinil.”
“Exposure of hRPE cells to 20–40 mM glucose produced time- and dose-dependent increases in sorbitol content and decreases in myo-inositol content that were partially blocked by the aldose reductase inhibitor sorbinil.”
“The coadministration of sorbinil (0.1 mmol/l) to 40 mmol/l glucose partially prevented the inhibitory effect of glucose on myo-[3H]inositol uptake.”
Modulation of myo-[3H]inositol uptake by glucose and sorbitol in cultured bovine lens epithelial cells. II. Characterization of high- and low-affinity myo-inositol transport sites.“The inhibition of myo-inositol uptake by cells chronically exposed to increased concentrations of glucose or galactose was due to a noncompetitive type of inhibition that was blocked by the addition of sorbinil.”
“The absolute rate of collagen synthesis, in proline molar terms, by pericytes in medium with 5 mM glucose was 3.3 +/- 1.… to 8.8 +/- 3.7 pmol 10(-7) cells 24 hr-1 when the glucose concentration was increased to 40 mM. Sorbinil (0.1 … of glucose , but ….”
“At a dose of 100&mgr;M sorbinil there was 59% inhibition of fibronectin accumulation in response to glucose , 48 h after the addition of the inhibitor (4.76 +/- 1.4 vs 11.53 +/- 1.41, mean +/- SD, p = 0.01, n = 3).”
“The increase in fibronectin concentration in response to glucose was inhibited by the aldose reductase inhibitor sorbinil.”
Renal proximal tubular cell fibronectin accumulation in response to glucose is polyol pathway dependent
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