Possible Interaction: Glucose and Somatropin

“Both hormones increased hepatic glucose output, but rhGH treatment was also associated with decreased carbohydrate oxidation and increased glucose and insulin concentrations, indicating subtle insulin resistance.”

“All patients had impaired glucose disposal due to insulin resistance but the area under the glucose curve increased significantly during somatropin treatment.”

“During a rapid tolbutamide tolerance test, serum HGH rose between 2.5- and 82-fold over the fasting levels within 10 to 70 minutes following the glucose nadir.”

“Mice treated for three days with hGH exhibited both increased fasting blood glucose concentrations and aggravated intolerance to administered glucose.”

“Fasting hGH was 25 ng/ml and suppressed only to 17 ng/ml with oral glucose.”

“It is suggested that HGH , although decreasing the peripheral utilization of glucose , is not a primary diabetogenic factor, since its insulinogenic action causes a compensatory hyperinsulinism, with normal glucose tolerance as the result.”

“There was a positive correlation between fetal glucose and HGH , as well as between the fetal insulin and HGH values.”

“ Oral glucose suppressed elevated HGH in all of the patients.”

“In controls as well as HGH deficient dwarfs, the mean maximal insulin responses to arginine and glucose were increased two- to fourfold by HGH treatment (5 nig.”

“A paradoxical rise in HGH concentration followed the glucose load.”