Possible Interaction: Glucose and Somatostatin

“Our data suggest that somatostatin increases insulin-stimulated muscle utilization of glucose through local mechanisms.”

“The changes in plasma glucagon, pancreatic polypeptide, and somatostatin levels may have been instrumental in the observed postprandial glucose and triglyceride effects.”

“Here we show that dapagliflozin-sensitive glucose- and insulin-dependent sodium uptake stimulates somatostatin secretion by elevating the cytoplasmic Na+ concentration ([Na+]i) and promoting intracellular Ca2+-induced Ca2+ release (CICR).”

“ Glucose caused pronounced stimulation of average insulin and somatostatin release.”

“In isolated perfused pancreas … rats, a rise in d-glucose concentration from 3.3 to 8.3 mM … rapid phasic stimulation of both insulin and somatostatin secretion and rapid fall in glucagon output, these changes being reversed when … of the hexose was brought back to its initial low level.”

“In cell culture, somatostatin alone inhibited glucose carbon recycling through the PC by 5.7%, which was increased to 19.8% in combination with oxythiamine, a competitive inhibitor of transketolase.”

“In further experiments, somatostatin (1.4 × 10−7M) blunted glucose mobil...”

“ Somatostatin (1.4 × 10−8M) also inhibited (38%, P < 0.05) glucagon (1.2 × 10−10M)-induced glucose release.”

“These data suggest the following conclusions: (a) the role of the cAMP-phosphodiesterase system on insulin biosynthesis is likely … be related to the rapid accumulation of pancreatic IRI which is observed in the perinatal period; (c) somatostatin, … glucose and cAMP-induced insulin biosynthesis as … these agents in human disease.”

“Serum growth hormone, somatostatin , and active ghrelin levels were decreased after glucose ingestion.”

“ glucose (mean change 3–10 min) was almost totally suppressed by SRIF (500 µg/h) and glucose utilization was reduced (p<0.0001).”