Possible Interaction: Glucose and Sitagliptin

“In contrast, sitagliptin lowered postprandial glucose to a greater degree in GG as compared with GA/AA individuals (P = 0.035).”

“ Sitagliptin treatment potentiated the GLP-1 response to glucose by 1.5-fold (P < 0.05).”

“ Fasting glucose decreased with both glimepiride and sitagliptin compared with placebo (P = 0.002).”

“…:Sitagliptin significantly decreased fasting levels of triglyceride (TG) (161 ± 90 vs. 130 ± 66 mg/dl, … (129 ± 29 vs. 116 ± 20 mg/dl, p < 0.01) in combination with glucose (150 ± 47 vs. 129 ± 27 mg/dl, p < 0.01) … vs. 6.6 ± 0.7 mg/dl, p < 0.001).”

“BACKGROUND In an earlier continuous glucose monitoring (CGM)-based study, we reported that sitagliptin not only reduced 24-h mean glucose levels but also suppressed postprandial glucose increases , thus reducing the range of glycemic fluctuations in type 2 diabetes patients.”

“ Sitagliptin resulted in greater suppression of endogenous glucose production and decreased meal appearance.”

“Following a meal tolerance test, 2-h postprandial glucose was significantly reduced with sitagliptin relative to placebo.”

“Like other DPP-4 inhibitors, sitagliptin reduces hemoglobin A1c (HbA1c), fasting and postprandial glucose by glucose-dependent stimulation of insulin secretion and inhibition of glucagon secretion.”

“Like other DPP-4 inhibitors, sitagliptin reduces hemoglobin A1c (HbA1c), fasting and postprandial glucose by glucose-dependent stimulation of insulin secretion and inhibition of glucagon secretion.”

“Considering the different, but complementary mechanisms of action by which AC and STGP induce lower glucose and insulin levels, combination therapy with both these agents offers great potential for treating diabetic cats in the future.”