Possible Interaction: Glucose and Simvastatin

“ Simvastatin compared to placebo significantly reduced plasma total cholesterol (7.9 vs 5.3 mmol·l−1), LDL-cholesterol (7.2 vs …·l−1), triglycerides (2.9 vs 2.1 mmol·l−1), free fatty acids (1106 vs 818 mmol−1) and glucose (7.4 vs …·l−1) levels.”

“In subgroup analysis of individual statins, use of atorvastatin, rosuvastatin, pitavastatin and simvastatin had significant association with increase in fasting glucose.”

“In the whole population, statin therapy (OR: 4.0, 95% CI 1.1–14.1, p<0.020), and in particular simvastatin and atorvastatin, was associated with increased risk of altered glucose levels or NOD.”

“Superoxide anion production, ER stress, and cell death induced by 27.5 mM dextrose were inhibited by therapeutic concentrations of simvastatin and pravastatin.”

“Superoxide anion production induced by 500 mg/dl dextrose was inhibited by therapeutic concentrations of rosuvastatin or simvastatin (10 nmol/l), whereas the increased levels of cellular endothelin 1 mRNA and endothelin 1 in culture media was inhibited by supratherapeutic concentrations of statins (> or =0.1 micromol/l).”

“Consistent with this idea simvastatin > 0.1 µM reversed activation of VGCCs by glucose but had no significant effect in the sugar's absence.”

“ Simvastatin treatment reduces the levels of glucose , lipid, leptin and neutrophil percentage, and improves airway inflammation and remodeling, which can be as a potential therapeutic target used in the treatment of obese asthma in humans.”

“In OE mice, simvastatin augmented muscular glucose uptake but impaired whole-body insulin sensitivity.”