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Last Updated: 2 years ago

Possible Interaction: Glucose and Serum Albumin, Human

supplement:

Glucose

Research Papers that Mention the Interaction

Incubation of HSA with D-glucose (20 mM, 37 degrees C for 21 days) led to the formation of Amadori products and fluorescent advanced glycation end-products (AGE).
Life sciences  •  1999  |  View Paper
HSA is known to react with glucose via the Maillard reaction, causing adverse effects on its ability to bind and deliver certain ligands, such as metals.
Metallomics : integrated biometal science  •  2020  |  View Paper
It suggests deleterious impairment in biochemical, electrochemical, spectroscopic, optical and fluidity properties of HSA at high concentrations of glucose.
International journal of biological macromolecules  •  2017  |  View Paper
These alterations were mainly attributed to the formation of crosslink between the lysine residues of HSA upon incubation with glucose.
International journal of biological macromolecules  •  2013  |  View Paper
Secondary and tertiary structural changes were also observed in HSA incubated with glucose in the presence or absence of PS through beta-sheet inducing effects.
Together our results indicated that PS has a stimulatory effect on glycation and fibrillation of HSA in the presence or absence of glucose , and could exacerbate complication of diabetes.
International journal of biological macromolecules  •  2013  |  View Paper
Thus, the extent of the Maillard reaction was influenced by the concentration of glucose and incubation time, such that longer exposure of HSA to glucose may have a more deleterious effect on its structure and especially on its half-life and turnover in the circulation.
Biochimica et biophysica acta  •  2007  |  View Paper
HSA was incubated with glucose in the 0-300mM range at 27 or 37 degrees C. The interaction of HSA with glucose showed two sets of binding sites.
Therefore, glucose interacts with multiple sites on HSA affecting its biochemical and biophysical properties.
The international journal of biochemistry & cell biology  •  2002  |  View Paper
Native HSA inhibited oxidant production by free glucose , as assessed by the hydroxylation of benzoic acid, but modified HSA had little effect.
The Biochemical journal  •  1993  |  View Paper