Possible Interaction: Glucose and Secretin

“ Secretin concentrations rose after acid both in the fasting state and during infusions of glucose.”

“Dupre demonstrated that secretin given intravenously with glucose increased its rate of disappearance from the blood, McIntyre and co‐workers established that hyperglycaemia evoked by oral glucose stimulated more insulin secretion than comparable hyperglycaemia produced by intravenous glucose and Marks and Samols established the insulinotropic properties of glucagon.”

“Refeeding with oral glucose suppressed the increased plasma glucagon, secretin and vaso-active intestinal polypeptide.”

“The post-race plasma levels of secretin and VIP showed a rapid and very marked decrease 15 min after ingestion of glucose , and the plasma levels had returned to control levels 60 min and 15 min respectively after glucose loading.”

“After infusion of glucose , the plasma insulin and C-peptide levels were significantly increased and remained at high levels during 30-min experiments, intravenous administration of secretin and CCK resulted in significant increases of pancreatic secretion including volume, bicarbonate, and protein output.”

“When glucose was simultaneously administered with secretin and CCK, pancreatic secretion was significantly increased, more than the effects achieved by the secretin and CCK.”

“ Secretin is a gastrointestinal hormone that stimulates insulin secretion and enhances the insulin response to glucose.”

“The study shows that gastric aspiration and/or glucose infusion suppressed the high plasma concentration of secretin and that factors other than hyperchlorhydria must be involved in the hypersecretinemia seen during starvation.”

“The intravenous infusion of 50 g glucose and the oral ingestion of 50 g glucose temporarily suppressed the high concentrations of VIP and secretin.”

“Ingestion of a mixed meal reduced the fasting plasma secretin by about 40% during the course, while oral glucose reduced the plasma secretin to the concentrations found in the control experiment.”

“Oral intake of glucose increased the peripheral plasma immunoreactive secretin (IRS) concentration in patients after total pancreatectomy with duodenectomy (p < 0.05) and in patients after total gastrectomy (p < 0.01).”