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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Glucose
drug:
Salicylic Acid
Research Papers that Mention the Interaction
“Infusion of sodium salicylate (SS), an inhibitor of endogenous prostaglandin synthesis, augmented acute insulin responses to glucose in normals (response before SS = 313+/-62%; during SS = 660+/-86%; P < 0.001).”
A role for prostaglandin E in defective insulin secretion and carbohydrate intolerance in diabetes mellitus.“At both doses of Epi, SS augmented the glucose disappearance rate (KG) after the glucose pulse (P < 0.001).”
“We have shown elsewhere … the uptake of glucose by isolated rat diaphragm muscle, incubated in a medium buffered with bicarbonate, is … by anoxia and by 2:4-dinitrophenol, sodium arsenite, sodium cyanide or sodium salicylate , as well as by insulin (Randle, 1956; … and Smith, 1957; Manchester et al., 1958).”
“In addition, sodium salicylate restricts basal lipolysis simulated by a high concentration of glucose and significantly diminishes the high glucose-enhanced lipolysis response to TNF-alpha.”
Salicylate blocks lipolytic actions of tumor necrosis factor-alpha in primary rat adipocytes.“…)sodium salicylate … glucose ; b) changes in alpha adrenergic activity are not related to the mechanism of action of salicylate; c) an increment in the cAMP concentration … on insulin secretion; d) the effect of salicylate on the microtubular system is indirect and probably mediated through an increment in pancreatic cAMP.”
“ Glucose and lactate levels in IC and AC were significantly increased after application of salicylate (350 mg/kg, i.p.),”
“…,sodium salicylate , phenylbutazone, or vincristine administered simultaneously …, further decreased the rates of D-glucose transport to 3.6, 2.0, 0.8, and 2.6 mumol/g/h, respectively, and the rates … L-tyrosine transport to 1.2, 1.9, 0.6 and 0.9 mumol/g/h, respectively.”
“Basal glucagon release was not changed by 1 mM sodium salicylate but the latter partially blocked its inhibition by 16.7 mM glucose.”
“Addition of salicylate concurrently with glucose greatly enhanced second-phase insulin secretion, but did not affect the first-phase peak, thereby converting the biphasic pattern to one that appeared to be monophasic.”
“However, when cultures were super-fused with salicylate both before and concurrent with stimulation by glucose , both the first-phase peak and the second phase of insulin secretion were increased, resulting in not only preservation but enhancement of the biphasic pattern.”
“Na salicylate 31 mM inhibits anaerobic glycolysis from glucose in bovine retina extracts.”
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