Possible Interaction: Glucose and Riboflavin

“ATP added to the incubation medium to a concentration of 10(-6)M or glucose in a 10(-3)M concentration enhanced riboflavin transport across the membrane.”

“When glucose or 2‐deoxy‐d‐glucose was used as a substrate for these erythrocytes, the rate of methaemoglobin reduction in these cells was accelerated more than two‐fold in the presence of riboflavin.”

“Concentrations of glucose as low as 25 mM were found to inhibit riboflavin transfer significantly.”

“Thus, materials causing tissue-fluid uptake (e.g., glucose and xylose) inhibit riboflavin transfer ; materials causing no tissue-fluid uptake (mannitol and glucose plus phlorizin) have no effect on drug transfer.”

“Thus, the transfer of riboflavin , salicylate, and sulfanilamide is significantly decreased in the presence of glucose.”

“After 24-h light exposure, dextrose solutions with admixtures of AH + FMN or AH + FMN + PS generated peroxides at concentrations similar to those observed in a 1% multivitamin solution, and over three times higher than those observed with FMN, PS, or AH alone.”

“On the other hand, growth experiments on glucose resulted in an eightfold increase in riboflavin yield but showed a 33% reduction in ICL specific activity compared to the wild-type grown on the same medium.”

“The addition of glucose enhanced the quantity of riboflavin excreted.”

“During non-growing cell incubation for 18hr, the addition of glucose markedly stimulated the formation of riboflavin , but the addition of pentoses (ribose, xylose, arabinose), ribitol and acetoin indicated no effect on the production.”