Possible Interaction: Glucose and Resveratrol

“We found that REV (50 mg/kg/d) can regulate glucose and lipid metabolism, improve insulin resistance and vascular permeability, and protect against the foam cells and cholesterol crystals formation in arterial vessel walls of T2DM rats.”

“In this paper, the competitive inhibition of intracellular uptake of glucose and dehydroascorbic acid in U937 and HL-60 cells by resveratrol is reported.”

“Molecular docking studies reveal that RSV can block the interaction of glucose with the GLUT family.”

“In groups II and III, resveratrol induced significant changes (p < 0.05) in the blood pressure, body mass index, as well as all parameters of the lipid profile, and glucose (in nondiabetic patients), compared to the control group.”

“ Resveratrol (20 μM) limits the steatosis induction in HepG2 cells by glucose and increased the mitochondrial activity of cells.”

“When resveratrol (5.0, 15.0, 25.0, 35.0 mg/L) was added to 25.0 mmol/L glucose medium , respectively, the apoptotic cells were decreased, the expression of pro-apoptotic protein Bax was decreased and anti-apoptotic protein Bcl-2 was increased.”

“ Glucose- and palmitate-mediated effects on NAMPT and SIRT1 were prevented by resveratrol in vitro.”

“These results suggest that glycolytic inhibition by RSV decreases the glucose usage of myoblast cells, therefore, prevents cell death caused by nutrient deprivation and hypoxic condition.”

“Supplemental evidences suggest that resveratrol precondition increases ADSC viability under high glucose stress via Sirt1 and IGF1R expressions.”

“Moreover, resveratrol reduced the caspase3 activity and Ox‐LDL expression in HG stimulated RRECs.”

“PON1 is a pivotal modulator in the role of resveratrol in reversing the RREC damage induced by HG.”