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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Glucose
drug:
Repaglinide
Research Papers that Mention the Interaction
“Analysis of the insulin and glucose concentrations throughout the meal test revealed that AUC for glucose (758 +/- 19 vs 780 +/- 28 mg/Lxmin; P = 0.02) was significantly lower after repaglinide than glimepiride administration despite similar AUC for insulin (2327 +/- 269 vs 2148 +/- 292 mU/Lxmin; P = 0.105).”
Repaglinide has more beneficial effect on cardiovascular risk factors than glimepiride: data from meal-test study.“There was a marked decrease in the dextrose infusion rate with administration of either repaglinide or glipizide at hypoglycemia compared with drug administration at euglycemia (P </= 0.006).”
“ Repaglinide significantly decreased the 5-h glucose AUC (P = 0.03).”
“ Repaglinide stimulates insulin release from beta-cells only in the presence of glucose.”
“Moreover, in the … 7 mM D-glucose , the lowest concentration of the drug required to cause a significant increase in insulin output decreased … 1.0 microM for meglitinide to 0.1 microM with A-4166, KAD-1229 or repaglinide and even close to 10 … the case of S 3075.”
Insulinotropic action of meglitinide analogs: concentration-response relationship and nutrient dependency.“ Repaglinide (RPG) regulates the amount of glucose by stimulating the pancreas to release insulin in the blood.”
Interaction of repaglinide with bovine serum albumin: Spectroscopic and molecular docking approaches
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