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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
Research Papers that Mention the Interaction
“Regulation of calcium fluxes in rat pancreatic islets: quinine mimics the dual effect of glucose on calcium movements.”
Meningococcal Septicaemia Presenting as Drug Hypersensitivity“The K+ channel blocker quinine reversed the effects of glucose and 2-deoxy-D-glucose on the Vm, suggesting that opening of K+ channels is involved in the hyperpolarizing effect of monosaccharides.”
Hyperpolarization of the cell membrane of mouse hepatocytes by metabolizable and nonmetabolizable monosaccharides“Whereas the effect of glucose in suppressing the mobilisation of potassium was mimicked by tolbutamide and quinine , it was antagonized by diazoxide.”
“After oral or intravenous administration of glucose , the plasma insulin levels were higher and the disappearance rate of glucose was greater in rats receiving quinine than in the controls.”
“Apamin (40–400 nM) increased the duration of the bursts of electrical activity, whereas quinine (50–100 μM) affected only slightly the steady‐state electrical response to glucose.”
“ Quinine (blocks Ca-dependent potassium permeability) elicited continuous spike activity in the presence of 16.7 mM glucose.”
“ Quinine also dramatically enhanced the cationic and the secretory response to intermediate concentrations of glucose , but had little effect on 45Ca net uptake, 45Ca fractional outflow rate and insulin release at a high glucose concentration (16.7 mM).”
“It is proposed that quinine unmasks a dual or discontinuous effect of glucose upon 86Rb+ handling by the islet cells.”
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